If you’ve been searching for shoulder pain relief due to arthritis, a rotator cuff injury, or general overuse, chances are you’ve come across corticosteroid injections as a common treatment option. But are they the best solution for your long-term joint health?
We are breaking down the difference between steroid shots and A2M injections, a natural alternative to cortisone that may offer more than just temporary relief.
For many people, corticosteroid injections are the go-to option when shoulder pain flares up. These injections work by quickly reducing inflammation, often easing pain within a few days. However, while they may feel like a miracle fix at first, corticosteroids only offer temporary relief, and in some cases, they can accelerate cartilage damage when used repeatedly.
If you’re looking for a more natural treatment for shoulder pain, A2M injections could be a better alternative.
Alpha-2 macroglobulin (A2M) is a large protein your body already produces. It plays a key role in protecting your joints by binding to the enzymes that contribute to cartilage breakdown and inflammation.
When injected directly into the shoulder joint, A2M captures destructive enzymes, helping to slow or stop degeneration. It not only reduces inflammation but also supports your body’s natural healing processes. This makes it an ideal option for people looking to avoid steroids or those seeking regenerative treatments for shoulder injuries.
Corticosteroids are synthetic medications that mimic cortisol, a hormone your adrenal glands naturally produce to regulate inflammation, metabolism, and immune response. When used in injection form, corticosteroids act as powerful anti-inflammatories, quickly reducing swelling and pain, especially acute flare-ups or injuries.
However, this fast-acting relief comes at a cost. Steroids suppress the immune system and do not encourage tissue healing. Over time, repeated steroid use can lead to joint tissue breakdown, weakened tendons, and cartilage degeneration.
In contrast, regenerative injections like A2M work with your body’s natural repair mechanisms, not against them. Rather than simply shutting down inflammation, A2M addresses the root cause of degeneration by neutralizing the harmful enzymes that damage cartilage. It promotes tissue protection and healing without the downside of synthetic suppression.
Feature | Corticosteroid Injections | A2M Injections |
---|---|---|
What it is | Man-made medicine to mimic cortisols' ability to reduce inflammation | Natural protein your body makes to protect joints from damage |
How it works | Quickly reduces inflammation and pain by calming immune system | Traps and blocks enzymes that break down cartilage, helping the joint heal |
Main-goal | Fast pain relief | Long-term joint health and healing |
How its made | Made in a lab | Comes from your own blood |
Risks | Can damage joints if used too often, may weaken tendons | Very low risk, uses your body's own natural protein |
For people who... | Need fast relief for a short time | Want to protect their joints and support long-term healing |
Ready to explore a natural alternative to cortisone? While steroids have their place, A2M offers something more: real healing potential and long-term joint support.
At Neil Riordan Center for Regenerative Medicine, we specialize in non-surgical treatments for shoulder pain and regenerative medicine. If you’re ready to learn more, we’re here to help you explore your options and find the best path forward.
Commentary for “Natural Alternative to Cortisone” provided by Alaa Gerais, NMD. For more about Dr. Gerais visit her bio page by clicking here.