The difference between quick pain relief and long-term joint support

Cortisone Shot vs
A Natural Alternative

Should You Choose Cortisone or a Natural Alternative?

If you’ve been searching for shoulder pain relief due to arthritis, a rotator cuff injury, or general overuse, chances are you’ve come across corticosteroid injections as a common treatment option. But are they the best solution for your long-term joint health?

We are breaking down the difference between steroid shots and A2M injections, a natural alternative to cortisone that may offer more than just temporary relief.

What Is the Best Injection for Shoulder Pain?

For many people, corticosteroid injections are the go-to option when shoulder pain flares up. These injections work by quickly reducing inflammation, often easing pain within a few days. However, while they may feel like a miracle fix at first, corticosteroids only offer temporary relief, and in some cases, they can accelerate cartilage damage when used repeatedly.

If you’re looking for a more natural treatment for shoulder pain, A2M injections could be a better alternative.

What is A2M (Alpha-2 Macroglobulin) and How Does It Work?

Alpha-2 macroglobulin (A2M) is a large protein your body already produces. It plays a key role in protecting your joints by binding to the enzymes that contribute to cartilage breakdown and inflammation.

When injected directly into the shoulder joint, A2M captures destructive enzymes, helping to slow or stop degeneration. It not only reduces inflammation but also supports your body’s natural healing processes. This makes it an ideal option for people looking to avoid steroids or those seeking regenerative treatments for shoulder injuries.

Why Regenerative Injections Like A2M Differ From Steroid Injections

Corticosteroids are synthetic medications that mimic cortisol, a hormone your adrenal glands naturally produce to regulate inflammation, metabolism, and immune response. When used in injection form, corticosteroids act as powerful anti-inflammatories, quickly reducing swelling and pain, especially acute flare-ups or injuries.

However, this fast-acting relief comes at a cost. Steroids suppress the immune system and do not encourage tissue healing. Over time, repeated steroid use can lead to joint tissue breakdown, weakened tendons, and cartilage degeneration.

In contrast, regenerative injections like A2M work with your body’s natural repair mechanisms, not against them. Rather than simply shutting down inflammation, A2M addresses the root cause of degeneration by neutralizing the harmful enzymes that damage cartilage. It promotes tissue protection and healing without the downside of synthetic suppression.

Feature Corticosteroid Injections A2M Injections
What it isMan-made medicine to mimic cortisols' ability to reduce inflammationNatural protein your body makes to protect joints from damage
How it worksQuickly reduces inflammation and pain by calming immune systemTraps and blocks enzymes that break down cartilage, helping the joint heal
Main-goalFast pain reliefLong-term joint health and healing
How its madeMade in a labComes from your own blood
RisksCan damage joints if used too often, may weaken tendonsVery low risk, uses your body's own natural protein
For people who...Need fast relief for a short timeWant to protect their joints and support long-term healing

Natural Relief for Shoulder Pain That Lasts

Ready to explore a natural alternative to cortisone? While steroids have their place, A2M offers something more: real healing potential and long-term joint support.

At Neil Riordan Center for Regenerative Medicine, we specialize in non-surgical treatments for shoulder pain and regenerative medicine. If you’re ready to learn more, we’re here to help you explore your options and find the best path forward.

Commentary for “Natural Alternative to Cortisone” provided by Alaa Gerais, NMD. For more about Dr. Gerais visit her bio page by clicking here.

Headshot of a women in a patterned shirt | Alaa Gerais